منابع مشابه
Aggressive invasion is observed in CD133−/A2B5+ glioma-initiating cells
Glioblastoma multiforme is the most common and fatal primary brain tumor in adults. Aggressive invasion of glioblastoma cells into brain tissue often limits complete surgical resection and contributes to therapeutic resistance. The cell surface marker, CD133, has been identified as a putative stem cell marker in normal and malignant brain tissues; CD133-/A2B5+ cells exhibit neural stem-like cel...
متن کاملInhibition of Glioma Cell Lysosome Exocytosis Inhibits Glioma Invasion
Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on lysosome exocytosis were studied to determine their effect on glioma cell migration and invasion. Both GPN and vacuolin-1 evidently inhibited migrat...
متن کاملMathematical Model for Glioma Cell Invasion
Experimental observations suggest that in the vicinity of the glioma-host interaction zone glioma cells secrete MMPs that dissolve the ECM composition and disturb the balance of the brain tissue [3]. In order to restore the natural balance, healthy brain cells try and produce more ECM components as well as secreting tissue inhibitor of the MMPs (TIMPs) [12]. In this paper we present a mathemati...
متن کاملAutocrine glutamate signaling promotes glioma cell invasion.
Malignant gliomas have been shown to release glutamate, which kills surrounding brain cells, creating room for tumor expansion. This glutamate release occurs primarily via system xC, a Na+-independent cystine-glutamate exchanger. We show here, in addition, that the released glutamate acts as an essential autocrine/paracrine signal that promotes cell invasion. Specifically, chemotactic invasion ...
متن کاملInositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma.
Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor and a central mediator of the unfolded protein response. In a human glioma model, inhibition of IRE1alpha correlated with down-regulation of prevalent proangiogenic factors such as VEGF-A, IL-1beta, IL-6, and IL-8. Significant up-regulation of antiangiogenic gene transcripts was also apparent. These transc...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.8.11383